sma4dSEMA4D is an oncogene that functions in a variety of tumors, including colorectal carcinoma (14), cervical cancer (15), ovarian cancer (16), soft tissue carcinomas (17), oral cancer (18Evans and colleagues describe a novel immunomodulatory function of semaphorin 4D (SEMA4D) and show that blocking SEMA4D enhances immune infiltration into tumor