sma4dBioGRID Interaction 297491 Between SEMA4D And PTPRC. sema domain, immunoglobulin domain (), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4DSMAD4 is the only common SMAD in TGF-β snaling that usually impedes immune cell activation in the tumor microenvironment. However, we demonstrated here that